Monoamine Mapping Using Mass Spectrometry Identified New Monoamine-rich Brain Nuclei
نویسندگان
چکیده
منابع مشابه
Visualization of monoamine oxidase in human brain.
11973 Monoamine oxidase (MAO; EC: 1.4.3.4) is a flavin containing enzyme which exists in two subtypes, MA0 A and MA0 B. MA0 A and B are different gene products and they also differ in their substrate and inhibitor selectivities and their cellular localizations. In human brain MA0 B predominates (B:A = 4:l) and is largely compartmentalized in cell bodies of serotonergic neurons and in glia. Many...
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Monoamine oxidases (MAO) A and B are approximately 60-kDa outer mitochondrial membrane flavoenzymes catalyzing the degradation of neurotransmitters and xenobiotic arylalkyl amines. Despite 70% identity of their amino acid sequences, both enzymes exhibit strikingly different properties when exposed to thiol-modifying reagents. Human MAO A and MAO B each contain 9 cysteine residues (7 in conserve...
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Newly synthesized compounds have been found to inhibit mitochondrial monoamine oxidase (MAO) in mouse brain and rat liver. A series of 2-acylamino-3-trrt-aminopropiophenones acted preferentially against M A 0 type B (2-phenylethylamine a s substrate) , apparent ly irreversibly. 2Decanoylamino-3-morpholinopropiophenone acted similarly irr live toward the cerebral MAO, producing a dose-related in...
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ژورنال
عنوان ژورنال: YAKUGAKU ZASSHI
سال: 2020
ISSN: 0031-6903,1347-5231
DOI: 10.1248/yakushi.20-00012-3